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Definitions and FAQs
Genetic Change (mutation, gene variant, genetic variant)
A genetic change (sometimes called a mutation, gene variant, or genetic variant) is a change in a DNA base sequence. While not all genetic changes will cause problems, sometimes, changes in genes can lead to changes in proteins and then the proteins don't work the way they are supposed to. This can lead to disease.
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Some genetic changes can be passed on from parent to child (inherited). These genetic changes occur in the germ cells, which are the cells that create sperm or eggs. Genetic changes that occur in the other cells in the body (known as somatic cells) do not get passed on to a person's children.
Genetic changes happen when new cells are being made and the DNA is copied. Also, exposures, such as high levels of radiation, can damage the DNA and cause genetic changes. However, most exposures will not result in genetic changes because each cell in the body has a system in place to check for DNA damage and repair the damage once it's found.”
https://www.cdc.gov/genomics-and-health/about/index.html
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Cancer cells usually have multiple genetic changes. These changes can lead to uncontrolled and abnormal cell growth and the spread of cancer to other parts of the body (metastasis).
Your genetic makeup (genes you inherited from your parents) may impact treatment, for some gynecologic cancers. Understanding inherited risks for cancers and tumors may also increase awareness of risk factors for you and your family and help your doctor determine your care including specialized cancer screening.
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A tumor’s genetic makeup (somatic) may help doctors determine specific types of cancer (diagnosis), possible treatment options, and the aggressiveness of a tumor (prognosis).
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